1,1'-Carbonyldiimidazole → HCID 22153698, compound

HRID 1111213Notes

Reaction equation

HRID 1111213 reaction equation
C(N1C=CN=C1)(N1[CH:7]=[CH:6]N=C1)=O.[CH3:13][N:14]1[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH2:22][C:23]#CC(O)=O)[CH2:16][CH2:15]1.[NH2:28][C:29]1[CH2:35][N:34]=[C:33]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=2[F:42])[C:32]2[C:43]([O:47][CH3:48])=[CH:44][CH:45]=[CH:46][C:31]=2[N:30]=1.[O:49]1CCCC1.CN(C)C=O>>[CH3:48][O:47][C:43]1[C:32]2[C:33]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=3[F:42])=[N:34][CH2:35][C:29]3[N:30]([C:21]([CH:20]([N:17]4[CH2:16][CH2:15][N:14]([CH3:13])[CH2:19][CH2:18]4)[CH2:6][CH3:7])=[CH:22][C:23](=[O:49])[N:28]=3)[C:31]=2[CH:46]=[CH:45][CH:44]=1

Participants

5

Reactant 4

HCID 682631,1'-CarbonyldiimidazoleHCID 15079755HCID 15079755, compoundHCID 21974620tetrahydrofuran N,N-dimethylformamideHCID 22153717HCID 22153717, compound

Product 1

HCID 22153698HCID 22153698, compound

Procedure

In the manner given in Example 21, carbonyldiimidazole, 6-(4-methylpiperazinyl)-2-hexynoic acid, and 2-amino-6-methoxy-5-(o-fluorophenyl)-3H-1,4-benzodiazepine was stirred in tetrahydrofuran-dimethylformamide to give 8-methoxy-1-[1-(4-methylpiperazinyl)propyl]-7-(o-fluorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one.

Sources & evidence

ORD record
ord-6ad5efa9aca14c03b9997d1e94510446
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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