Propionic anhydride → HCID 22153714, compound

HRID 1111227Notes

Reaction equation

HRID 1111227 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[CH:13][C:14](=[O:16])[N:15]=[C:10]3[CH:9]([OH:17])[N:8]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[C:6]=2[CH:25]=1.[C:26]([O:30]C(=O)CC)(=[O:29])[CH2:27][CH3:28]>N1C=CC=CC=1>[C:26]([OH:30])(=[O:29])[CH2:27][CH3:28].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[CH:13][C:14](=[O:16])[N:15]=[C:10]3[CH:9]([OH:17])[N:8]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[C:6]=2[CH:25]=1

Participants

4

Reactant 2

HCID 31263Propionic anhydrideHCID 15079826HCID 15079826, compound

Product 1

HCID 22153714HCID 22153714, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 9-chloro-5-hydroxy-7-(o-chlorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one in pyridine was added propionic anhydride. The mixture was allowed to stand at room temperature for 6 hours and was then poured into ice water. The solids thus produced were recovered by filtration and recrystallized from methanol to give 9-chloro-5-hydroxy-7-(o-chlorophenyl)pyrimido[1,2-a][1,4]benzodiazepin-3(5H)-one propionate.

Workup

  1. customThe solids thus produced
  2. filtrationwere recovered by filtration
  3. customrecrystallized from methanol

Sources & evidence

ORD record
ord-dcc834aab60d40dda7d6c12d2127be38
Source dataset
uspto-grants-1990_12
Patent number
US04978753

Reaction notes

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