Acetone → Methyl 3-amino-4-phenoxy-5-sulfamoylbenzoate

HRID 1111616노트

반응식

HRID 1111616 반응식
[CH3:1][O:2][C:3](=[O:24])[C:4]1[CH:9]=[C:8]([S:10](=[O:13])(=[O:12])[NH2:11])[C:7]([O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:6]([N+:21]([O-])=O)[CH:5]=1.CC(C)=O>CO.[Ni]>[CH3:1][O:2][C:3](=[O:24])[C:4]1[CH:9]=[C:8]([S:10](=[O:13])(=[O:12])[NH2:11])[C:7]([O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:6]([NH2:21])[CH:5]=1

참가 물질

5

반응물 2

HCID 180AcetoneHCID 53854447Methyl 3-nitro-4-phenoxy-5-sulfamoylbenzoate

생성물 1

HCID 13020993Methyl 3-amino-4-phenoxy-5-sulfamoylbenzoate

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

35 g (~0.1 mol) of 3-nitro-4-phenoxy-5-sulphamylbenzoic acid methyl ester are suspended in 150 ml of methanol and are hydrogenated with Raney nickel (5-10%) in an autoclave at 40°-50° and 100 atmospheres gauge. The precipitated amino compound is dissolved by the addition of acetone on a steambath and the Raney nickel is removed by filtration.

후처리

  1. customthe Raney nickel is removed by filtration

출처 및 근거

ORD 기록
ord-eab54a3790a847a38e9f6b08e40e0fa8
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04118397

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