Hydrochloric Acid → HCID 20315354, compound

HRID 1111645Notes

Reaction equation

HRID 1111645 reaction equation
[CH3:1][Mg]I.[Cl:4][C:5]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:6]=1[CH:12]([CH2:15][CH2:16][CH2:17][CH3:18])[CH:13]=[O:14].O.Cl>CCOCC>[Cl:4][C:5]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:6]=1[CH:12]([CH2:15][CH2:16][CH2:17][CH3:18])[CH:13]([OH:14])[CH3:1]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 86735890HCID 86735890, compoundHCID 178418373HCID 178418373, compound

Product 1

HCID 20315354HCID 20315354, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To 14.3 g (0.088 mole) of methylmagnesium iodide in 75 ml of ether is slowly added at less than 10°, 14.5 g (0.059 mole) of the α-(2,4-dichlorophenyl) hexanal. When the addition is complete, the reaction is stirred for 1 hour then heated up to reflux for 2 hours. The reaction is cooled and poured into water. The mixture is acidified with hydrochloric acid and the oil which separates is extracted out with water. The ether solution is dried and concentrated to give 11.7 g (76%) of the crude product.

Workup

  1. additionWhen the addition
  2. temperaturethen heated up
  3. temperatureto reflux for 2 hours
  4. temperatureThe reaction is cooled
  5. extractionthe oil which separates is extracted out with water
  6. dry with materialThe ether solution is dried
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-0395c2b6ac72450eb0a0460e29be90d8
Source dataset
uspto-grants-1978_10
Patent number
US04118461

Reaction notes

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