Tetrahydrofuran → 2-Chloroethyl 2-(4-chlorophenoxy)-2-methylpropionate

HRID 1111779Notes

Reaction equation

HRID 1111779 reaction equation
[Cl:1]C(O)C.C1C[O:8][CH2:7][CH2:6]1.[Cl:10][C:11]1[CH:23]=[CH:22][C:14]([O:15][C:16]([CH3:21])([CH3:20])[C:17](Cl)=[O:18])=[CH:13][CH:12]=1>C(N(CC)CC)C>[Cl:10][C:11]1[CH:23]=[CH:22][C:14]([O:15][C:16]([CH3:21])([CH3:20])[C:17]([O:8][CH2:7][CH2:6][Cl:1])=[O:18])=[CH:13][CH:12]=1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 27813122-(4-Chlorophenoxy)-2-methylpropanoyl chlorideHCID 126390351-Chloroethan-1-ol

Product 1

HCID 1040992-Chloroethyl 2-(4-chlorophenoxy)-2-methylpropionate

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

To a solution of 80.5 g of chloro-ethanol (1 mole) in THF containing 101 g (1 mole) of triethylamine are added, dropwise with stirring, 233 g (1 mole) of p-chlorophenoxy-2-methylpropionic acid chloride. The triethylamine hydrochloride is filtered, and the ester formed is distilled; it is identical to that obtained under 6.1.1.; the synthesis of (VI) is continued as under 6.1.2., and then 6.1.3.

Workup

  1. filtrationThe triethylamine hydrochloride is filtered

Sources & evidence

ORD record
ord-43a220cce73d4ce1ab09052f2fec25dd
Source dataset
uspto-grants-1978_10
Patent number
US04118583

Reaction notes

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