Hydrochloric Acid → 3-(3-Fluoro-4-methoxyphenyl)prop-2-enoic acid
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH:5]=O.C(O)(=O)[CH2:13][C:14]([OH:16])=[O:15].N1CCCCC1.Cl>N1C=CC=CC=1.O>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH:5]=[CH:13][C:14]([OH:16])=[O:15]Participants
7
Reactant 4
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 80 °C
Procedure
A mixture of 3-fluoro-anisaldehyde (1.5g) and malonic acid (2.08g) in 5 ml pyridine was warmed until clear solution was obtained. To this mixture piperidine (0.4ml) was added and then the content of the flask was heated at 80° C. for 1 hour. It was further refluxed for 3 hours. At the end of this period the mixture was poured into 50ml of cold water. It was then acidified by adding 5ml of concentrated hydrochloric acid. Upon addition of acid, the solid separated, which was filtered and washed with cold water. The material was dried. Yield 1.7 g. The crude material was crystallized from a mixture of tetrahydrofuran and water. m.p. 227°-230° C.
Workup
- temperaturewas warmed until clear solution
- customwas obtained
- temperatureIt was further refluxed for 3 hours
- additionUpon addition of acid
- customthe solid separated
- filtrationwhich was filtered
- washwashed with cold water
- customThe material was dried
- customThe crude material was crystallized from a mixture of tetrahydrofuran and water
Sources & evidence
- ORD record
- ord-5194ecb370b4413d934ecdb2d9f1749a
- Source dataset
- uspto-grants-1978_10
- Patent number
- US04120867
Reaction notes
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