HRID1112350

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID134375

1-Methyl-3-[(morpholin-2-yl)methyl]-1,3-dihydro-2H-benzimidazol-2-one--hydrogen chloride (1/1)

C13H18ClN3O2

$结构：O=C(O)/C=C\C(=O)O$

HCID444266

Maleic acid

C4H4O4

结构：Cl.O=c1n(CC2CN(Cc3ccccc3)CCO2)c2ncccc2n1-c1ccccc1

HCID70601730

未命名化合物

PRODUCTS

生成物

$结构：O=C(O)/C=C\C(=O)O.O=c1n(CC2CNCCO2)c2ncccc2n1-c1ccccc1$

HCID86736079

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

2 次

PROCEDURE

实验过程

19 g of 4-benzyl-2-(1-phenyl-2,3-dihydro-imidazo-(4,5-b)pyridin-2-on-3yl-methyl)-morpholine hydrochloride are treated in accordance with part (a) of Example 2. The oil obtained is dissolved in hot isopropanol. A hot solution of maleic acid in isopropanol is added. The salt precipitates slowly. Recrystallization from isopropanol gives 5 g of 2-(1-phenyl-2,3-dihydro-imidazo-(4,5-b)pyridin-2-on-3-yl-methyl)-morpholine maleate, m.p. 190° C.

WORKUP

后处理

customThe oil obtained
customThe salt precipitates slowly
customRecrystallization from isopropanol