反应详情

1.99 grams of 1-chloro-3,5-dimethyl-adamantane were heated with 0.9 gram urea for about 40 minutes at 220° C. The heating was carried out in a closed vessel in an oil bath with a thermostat. After cooling, the reaction product was pulverized and made into a paste with 50 ml. water. The water phase was brought to a pH between 3 and 5 by dropwise addition of concentrated HCl. The acidified water phase was extracted with two 10-ml. ether portions. Next the water phase was brought to a pH between 12 and 13 by addition of sodium hydroxide, and stirred for 5 minutes. After stirring, the alkaline water phase was extracted with four portions of ether, 10 ml. each. The combined ether extracts were dried over potassium hydroxide. By bubbling dried hydrogen chloride through the solution, 1-amino-3,5-dimethyl-adamantane hydrochloride was precipitated. The yield was 1.7 grams (78% of the theoretical yield). The product did not melt until 300° C.

1. customThe heating was carried out in a closed vessel in an oil bath with a thermostat
2. temperatureAfter cooling
3. extractionThe acidified water phase was extracted with two 10-ml
4. additionNext the water phase was brought to a pH between 12 and 13 by addition of sodium hydroxide
5. stirringAfter stirring
6. extractionthe alkaline water phase was extracted with four portions of ether, 10 ml
7. dry with materialThe combined ether extracts were dried over potassium hydroxide
8. customBy bubbling dried hydrogen chloride through the solution, 1-amino-3,5-dimethyl-adamantane hydrochloride
9. customwas precipitated
10. customThe yield was 1.7 grams (78% of the theoretical yield)
11. customdid not melt until 300° C.