Phenethylamine → N-[[2-[3-(4-Morpholinyl)propoxy]phenyl]methylene]benzeneethanamine

HRID 1112441Notes

Reaction equation

HRID 1112441 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=2[CH:13]=O)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH2:19]([NH2:27])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C1(C)C=CC=CC=1>[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=2[CH:13]=[N:27][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 1001PhenethylamineHCID 137952602-(3-Morpholin-4-YL-propoxy)-benzaldehyde

Product 1

HCID 20394050N-[[2-[3-(4-Morpholinyl)propoxy]phenyl]methylene]benzeneethanamineYield 76.5%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2-[3-(4-Morpholinyl)propoxy]benzaldehyde (31.7g) is reacted with 15.8g of phenethylamine in 130 ml of toluene following the procedure described in Example 1A to yield 34.3g of product as an oil, boiling point 215°-219° C at 0.2-0.3 mm of Hg.

Sources & evidence

ORD record
ord-da899c30bccc4b958efefe2f136049f3
Source dataset
uspto-grants-1978_10
Patent number
US04122255

Reaction notes

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