Sodium borohydride → N-[[2-[3-(1-Piperidinyl)propoxy]phenyl]methyl]benzeneethanamine

HRID 1112450노트

반응식

HRID 1112450 반응식
[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH:17]=[N:18][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[BH4-].[Na+]>CO>[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH2:17][NH:18][CH2:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 21322776N-[[2-[3-(1-Piperidinyl)propoxy]phenyl]methylene]benzeneethanamine

생성물 1

HCID 21322750N-[[2-[3-(1-Piperidinyl)propoxy]phenyl]methyl]benzeneethanamine수율 80.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

N-[[2-[3-(1-Piperidinyl)propoxy]phenyl]methylene]benzeneethanamine (61.5g) is reduced with 20g of sodium borohydride in 320ml of methanol following the procedure described in Example 1B to yield 49.6g of product as an oil, boiling point 216°-221° C at 0.3-0.4mm of Hg.

출처 및 근거

ORD 기록
ord-2850cc6f559c4d1da12e93892a134dc9
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04122255

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