Sodium Hydroxide → HCID 22762252, compound

HRID 1112573Notes

Reaction equation

HRID 1112573 reaction equation
[CH:1]([C:4]1[CH:20]=[CH:19][C:7]([CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([N:16]=[C:17]=[O:18])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].Cl.[NH2:22][OH:23].[OH-:24].[Na+]>C(Cl)Cl.O>[CH:1]([C:4]1[CH:20]=[CH:19][C:7]([C:8]([O:9][C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]([NH:22][OH:23])=[O:18])=[CH:12][CH:11]=2)=[O:24])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 22762250HCID 22762250, compound

Product 1

HCID 22762252HCID 22762252, compoundYield 77.5%

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 6344DichloromethaneSolvent

Procedure

A solution of 4-(4-isopropylbenzyloxy)phenyl isocyanate (4.5 g) in methylene chloride (50 ml) is added dropwise to a solution of hydroxylamine hydrochloride (5.4 g) and sodium hydroxide (4 g) in water (15 ml) at a temperature below 20° C. The reaction mixture is diluted with water and filtered to give N-[4-(4-isopropylbenzoyloxy)-phenyl]-N'-hydroxyurea (4.1 g).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-944bcf72eaab4c1e840bface881127bf
Source dataset
uspto-grants-1978_10
Patent number
US04123256

Reaction notes

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