Water → HCID 22762753, compound

HRID 1112727Notes

Reaction equation

HRID 1112727 reaction equation
Cl[CH2:2][C:3]1[O:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)=[CH:6][N:7]=1.[C:15]1(=[O:25])[NH:19][C:18](=[O:20])[C:17]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]12.[K].O>CN(C)C=O>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[O:4][C:3]([CH2:2][N:19]3[C:18](=[O:20])[C:17]4=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]4[C:15]3=[O:25])=[N:7][CH:6]=2)=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 962WaterHCID 7369662-(Chloromethyl)-5-(4-chlorophenyl)-1,3-oxazoleHCID 24194345Phthalimide potassium salt

Product 1

HCID 22762753HCID 22762753, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A suspension of 2.3 g of 2-chloromethyl-5-(4-chlorophenyl) oxazole and 1.94 g of potassium phthalimide in 15 ml of dimethylformamide was stirred at room temperature for 1 hour. The reaction mixture was poured into 300 ml of water, and the resultant precipitate was filtered and recrystallized from ethanol to give 2.4 g (71 percent) of N-[5-(4-chlorophenyl)-2-oxazolyl]methylphthalimide.

Workup

  1. filtrationthe resultant precipitate was filtered
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-8ad7817209bf4956af5e7896da38c748
Source dataset
uspto-grants-1978_10
Patent number
US04123541

Reaction notes

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