反应详情

2-Bromoacetophenone (39.9 g; 0.2 mole) and 2-acetoxythioacetamide (30 g; 0.225 mole) were dissolved in dioxan (150 ml). The mixture was stirred and heated on a steam bath for 15 minutes, yielding a mass of crystals. Aqueous 5N HCl (40 ml) was added and the heating continued for a further 30 minutes. The dioxan was evaporated under vacuum and the residue neutralised with aqueous Na2CO3 solution. The solid was collected, washed with water and dried. After recrystallisation from benzene the product weighed 33.5 g (87%) and had a m.p. of 88°-9° C.

1. temperatureheated on a steam bath for 15 minutes
2. customyielding a mass of crystals
3. customThe dioxan was evaporated under vacuum
4. customThe solid was collected
5. washwashed with water
6. customdried
7. customAfter recrystallisation from benzene the product