1-Phenylpiperazine → 5-phenyl-2-[(4-phenylpiperazin-1-yl)methyl]-1,3-oxazole

HRID 1112734Notes

Reaction equation

HRID 1112734 reaction equation
Cl[CH2:2][C:3]1[O:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][N:7]=1.[C:14]1([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[C:8]1([C:5]2[O:4][C:3]([CH2:2][N:23]3[CH2:24][CH2:25][N:20]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH2:21][CH2:22]3)=[N:7][CH:6]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 70961-PhenylpiperazineHCID 10340Sodium CarbonateHCID 23076542-(chloromethyl)-5-phenyl-1,3-oxazole

Product 1

HCID 86882535-phenyl-2-[(4-phenylpiperazin-1-yl)methyl]-1,3-oxazole

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-choromethyl-5-phenyloxazole (3.87 g; 0.02 mole) and N-phenylpiperazine (3.25 g; 0.02 mole) in absolute ethanol (60 ml) was boiled and stirred with finely powdered anhydrous sodium carbonate (5 g) for 6 hours.

Sources & evidence

ORD record
ord-bdc4838df5444f51b73e2c351c2ec3e7
Source dataset
uspto-grants-1978_10
Patent number
US04123529

Reaction notes

Loading…