Aluminium lithium hydride → HCID 22763199, compound

HRID 1112751Notes

Reaction equation

HRID 1112751 reaction equation
[NH:1]1[CH:5]2[CH:6](Cl)[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[C:2]1([O:18][CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[C:3]1[CH:17]=[CH:16][CH:15]=[CH:14][C:4]=12.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[NH:1]1[CH:5]2[CH2:6][C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[C:2]1([O:18][CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[C:3]1[CH:17]=[CH:16][CH:15]=[CH:14][C:4]=12

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 22763200HCID 22763200, compound

Product 1

HCID 22763199HCID 22763199, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

The compound of Example 8 was dissolved in tetrahydrofuran and added to a suspension of lithium aluminum hydride in tetrahydrofuran and refluxed for 3 hrs. After washing with water, and extraction with ether, the subject compound was obtained; nmr (CDCl3): τ 2.25-3.15 (m, 8H, arom), 5.21 (br d, 1H, J = 5Hz, ##STR17## 5.90-6.90 (m, 5H, PhCH2 --, --OCH2 --, and --NH--), 7.25 (br t, 2H, --CH2N(CH3)2), and 7.63 (s, 6H, --N(CH3)2).

Workup

  1. temperaturerefluxed for 3 hrs
  2. washAfter washing with water, and extraction with ether
  3. customthe subject compound was obtained

Sources & evidence

ORD record
ord-2b5d9818a78e4b96b684790439809944
Source dataset
uspto-grants-1978_10
Patent number
US04123546

Reaction notes

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