Water → 2-Amino-4-[1-[8-(1-methylpyrazol-4-yl)-1-oxo-2-phenylisoquinolin-3-yl]ethylamino]pyrimidine-5-carbonitrile
Reaction equation
[CH3:39][C:40]#[N:41].[Cu:119]([I:120])[I:121].[NH2:1][c:2]1[n:3][cH:4][c:5]([I:34])[c:6]([NH:8][CH:9]([CH3:10])[c:11]2[n:12](-[c:28]3[cH:29][cH:30][cH:31][cH:32][cH:33]3)[c:13](=[O:27])[c:14]3[c:15](-[c:21]4[cH:22][n:23][n:24]([CH3:26])[cH:25]4)[cH:16][cH:17][cH:18][c:19]3[cH:20]2)[n:7]1.[Na:35][C:36]#[N:37].[OH2:38].[Pd:42].[c:100]1([P:101]([c:102]2[cH:103][cH:104][cH:105][cH:106][cH:107]2)[c:108]2[cH:109][cH:110][cH:111][cH:112][cH:113]2)[cH:114][cH:115][cH:116][cH:117][cH:118]1.[c:43]1([P:44]([c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[c:51]2[cH:52][cH:53][cH:54][cH:55][cH:56]2)[cH:57][cH:58][cH:59][cH:60][cH:61]1.[c:62]1([P:63]([c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)[c:70]2[cH:71][cH:72][cH:73][cH:74][cH:75]2)[cH:76][cH:77][cH:78][cH:79][cH:80]1.[c:81]1([P:82]([c:83]2[cH:84][cH:85][cH:86][cH:87][cH:88]2)[c:89]2[cH:90][cH:91][cH:92][cH:93][cH:94]2)[cH:95][cH:96][cH:97][cH:98][cH:99]1>>[NH2:1][c:2]1[n:3][cH:4][c:5]([C:36]#[N:37])[c:6]([NH:8][CH:9]([CH3:10])[c:11]2[n:12](-[c:28]3[cH:29][cH:30][cH:31][cH:32][cH:33]3)[c:13](=[O:27])[c:14]3[c:15](-[c:21]4[cH:22][n:23][n:24]([CH3:26])[cH:25]4)[cH:16][cH:17][cH:18][c:19]3[cH:20]2)[n:7]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-4fe7f75c244e43b28af931a798043610
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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