Chloride → Tert-butyl 5-tert-butylpyridin-2-ylcarbamate

HRID 1115087Notes

Reaction equation

HRID 1115087 reaction equation
[Br:10][c:11]1[cH:12][cH:13][c:14]([NH:17][C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[n:15][cH:16]1.[C:5]([CH3:6])([CH3:7])([CH3:8])[Mg+:9].[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1.[Cl-:4].[Cu:1][C:2]#[N:3]>>[C:5]([CH3:6])([CH3:7])([CH3:8])[c:11]1[cH:12][cH:13][c:14]([NH:17][C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[n:15][cH:16]1

Participants

6

Reactant 5

HCID 312ChlorideHCID 8028TetrahydrofuranHCID 162178432-(Boc-amino)-5-bromopyridineHCID 178418546HCID 178418546, compoundHCID 178448412HCID 178448412, compound

Product 1

HCID 66642981Tert-butyl 5-tert-butylpyridin-2-ylcarbamate

Sources & evidence

ORD record
ord-c2ccbcceecef403195d5b381adb60595
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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