Tetrahydrofuran → 3,4-difluoro-2-{2-fluoro-4-[3-(tetrahydro-2H-pyran-2-yloxy)-1-propynyl]anilino}benzoic acid
Reaction equation
[CH2:41]1[O:42][CH2:43][CH2:44][CH2:45]1.[CH3:32][Si:33]([N-:34][Si:35]([CH3:36])([CH3:37])[CH3:38])([CH3:39])[CH3:40].[F:13][c:14]1[c:15]([NH2:16])[cH:17][cH:18][c:19]([C:21]#[C:22][CH2:23][O:24][CH:25]2[O:26][CH2:27][CH2:28][CH2:29][CH2:30]2)[cH:20]1.[F:1][c:2]1[c:3]([C:4](=[O:5])[OH:6])[cH:7][cH:8][c:9]([F:12])[c:10]1[F:11].[Li+:31]>>[c:2]1([NH:16][c:15]2[c:14]([F:13])[cH:20][c:19]([C:21]#[C:22][CH2:23][O:24][CH:25]3[O:26][CH2:27][CH2:28][CH2:29][CH2:30]3)[cH:18][cH:17]2)[c:3]([C:4](=[O:5])[OH:6])[cH:7][cH:8][c:9]([F:12])[c:10]1[F:11]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-3db8fc39283447d889270716e3a6f088
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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