Tetrahydrofuran → 2-Chloro-5-fluoro-6-(5-isopropoxy-1H-pyrazol-3-ylamino)nicotinonitrile
Reaction equation
[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[CH3:22][CH2:23][N:24]([CH2:25][CH3:26])[CH2:27][CH3:28].[CH:1]([CH3:2])([CH3:3])[O:4][c:5]1[cH:6][c:7]([NH2:10])[n:8][nH:9]1.[Cl:11][c:12]1[c:13]([C:14]#[N:15])[cH:16][c:17]([F:21])[c:18]([Cl:20])[n:19]1>>[CH:1]([CH3:2])([CH3:3])[O:4][c:5]1[cH:6][c:7]([NH:10][c:18]2[c:17]([F:21])[cH:16][c:13]([C:14]#[N:15])[c:12]([Cl:11])[n:19]2)[n:8][nH:9]1Participants
5
Sources & evidence
- ORD record
- ord-20e0f307de9548889c6be6c90bf0af93
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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