Water → 6-[3-(4-chloro-5-fluoro-2,3-dihydroindol-1-yl)-2-oxopyrrolidin-1-yl]-N-(1,3-thiazol-2-yl)pyridine-3-sulfonamide

HRID 1116096Notes

Reaction equation

HRID 1116096 reaction equation
[CH2:1]([P:2]([CH2:3][CH2:4][CH2:5][CH3:6])[CH2:7][CH2:8][CH2:9][CH3:10])[CH2:11][CH2:12][CH3:13].[CH2:48]1[O:49][CH2:50][CH2:51][CH2:52]1.[Cl:14][c:15]1[c:16]2[c:20]([cH:21][cH:22][c:23]1[F:24])[N:19]([CH:25]([C:26](=[O:27])[NH:28][c:29]1[n:30][cH:31][c:32]([S:35]([NH:36][c:37]3[s:38][cH:39][cH:40][n:41]3)(=[O:42])=[O:43])[cH:33][cH:34]1)[CH2:44][CH2:45][OH:46])[CH2:18][CH2:17]2.[OH2:47]>>[Cl:14][c:15]1[c:16]2[c:20]([cH:21][cH:22][c:23]1[F:24])[N:19]([CH:25]1[C:26](=[O:27])[N:28]([c:29]3[n:30][cH:31][c:32]([S:35]([NH:36][c:37]4[s:38][cH:39][cH:40][n:41]4)(=[O:42])=[O:43])[cH:33][cH:34]3)[CH2:45][CH2:44]1)[CH2:18][CH2:17]2

Participants

5

Reactant 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 13831TributylphosphineHCID 765874132-(4-chloro-5-fluoro-2,3-dihydroindol-1-yl)-4-hydroxy-N-[5-(1,3-thiazol-2-ylsulfamoyl)-2-pyridinyl]butanamide

Product 1

HCID 744115436-[3-(4-chloro-5-fluoro-2,3-dihydroindol-1-yl)-2-oxopyrrolidin-1-yl]-N-(1,3-thiazol-2-yl)pyridine-3-sulfonamide

Sources & evidence

ORD record
ord-7d80f3335f6a4e199dffbb100ee0d382
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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