Dimethylformamide → Tert-butyl 2-[[5-[3-(2-phenylethoxymethyl)phenyl]-3-pyridinyl]oxymethyl]azetidine-1-carboxylate

HRID 1116136Notes

Reaction equation

HRID 1116136 reaction equation
[C:18]([CH3:19])([CH3:20])([CH3:21])[O:22][C:23](=[O:24])[N:25]1[CH:26]([CH2:29][O:30][c:31]2[cH:32][n:33][cH:34][c:35]([Sn:37]([CH3:38])([CH3:39])[CH3:40])[cH:36]2)[CH2:27][CH2:28]1.[Cu:46][I:47].[I:1][c:2]1[cH:3][c:4]([CH2:8][O:9][CH2:10][CH2:11][c:12]2[cH:13][cH:14][cH:15][cH:16][cH:17]2)[cH:5][cH:6][cH:7]1.[O:41]=[CH:42][N:43]([CH3:44])[CH3:45].[cH:48]1[cH:49][cH:50][c:51]([P:52]([Pd:53]([P:54]([c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)([c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)[c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)([P:73]([c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)([c:80]2[cH:81][cH:82][cH:83][cH:84][cH:85]2)[c:86]2[cH:87][cH:88][cH:89][cH:90][cH:91]2)[P:92]([c:93]2[cH:94][cH:95][cH:96][cH:97][cH:98]2)([c:99]2[cH:100][cH:101][cH:102][cH:103][cH:104]2)[c:105]2[cH:106][cH:107][cH:108][cH:109][cH:110]2)([c:111]2[cH:112][cH:113][cH:114][cH:115][cH:116]2)[c:117]2[cH:118][cH:119][cH:120][cH:121][cH:122]2)[cH:123][cH:124]1>>[c:2]1(-[c:35]2[cH:34][n:33][cH:32][c:31]([O:30][CH2:29][CH:26]3[N:25]([C:23]([O:22][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:24])[CH2:28][CH2:27]3)[cH:36]2)[cH:3][c:4]([CH2:8][O:9][CH2:10][CH2:11][c:12]2[cH:13][cH:14][cH:15][cH:16][cH:17]2)[cH:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 593714071-Iodo-3-(phenethoxymethyl)benzeneHCID 72272949Tert-butyl 2-[(5-trimethylstannyl-3-pyridinyl)oxymethyl]azetidine-1-carboxylateHCID 178420554HCID 178420554, compound

Product 1

HCID 72273097Tert-butyl 2-[[5-[3-(2-phenylethoxymethyl)phenyl]-3-pyridinyl]oxymethyl]azetidine-1-carboxylate

Sources & evidence

ORD record
ord-ec3421496ff944c3b89220f03708eb80
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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