Tetrahydrofuran → 2-Chloromethyl-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide

HRID 1116494Notes

Reaction equation

HRID 1116494 reaction equation
[CH2:19]([N:20]([CH:21]([CH3:22])[CH3:23])[CH:24]([CH3:25])[CH3:26])[CH3:27].[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([N:13]2[CH2:14][CH2:15][O:16][CH2:17][CH2:18]2)[c:7]2[c:8]1[n:9][c:10]([NH2:12])[s:11]2.[Cl:28][CH2:29][c:30]1[cH:31][c:32]([C:33](=[O:34])[Cl:35])[cH:36][cH:37][n:38]1.[O:39]1[CH2:40][CH2:41][CH2:42][CH2:43]1>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([N:13]2[CH2:14][CH2:15][O:16][CH2:17][CH2:18]2)[c:7]2[c:8]1[n:9][c:10]([NH:12][C:33]([c:32]1[cH:31][c:30]([CH2:29][Cl:28])[n:38][cH:37][cH:36]1)=[O:34])[s:11]2

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 81531DiisopropylethylamineHCID 114028614-Methoxy-7-morpholinobenzo[d]thiazol-2-amineHCID 219192322-(Chloromethyl)pyridine-4-carbonyl chloride

Product 1

HCID 229933982-Chloromethyl-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide

Sources & evidence

ORD record
ord-37a8059ae47142d2bdb9d2bf4416a368
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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