Dimethylformamide → tert-butyl 3-bromo-1-[[4-methyl-1-(methylamino)-1-oxopentan-2-yl]carbamoyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-7-carboxylate

HRID 1116518Notes

Reaction equation

HRID 1116518 reaction equation
[B-:40]([F:41])([F:42])([F:43])[F:44].[Br:1][c:2]1[n:3][c:4]([C:18](=[O:19])[OH:20])[c:5]2[n:6]1[CH2:7][CH2:8][N:9]([C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:10]2.[CH3:21][NH:22][C:23]([CH:24]([NH2:25])[CH2:26][CH:27]([CH3:28])[CH3:29])=[O:30].[CH:31]([N:32]([CH2:33][CH3:34])[CH:35]([CH3:36])[CH3:37])([CH3:38])[CH3:39].[O:62]=[CH:63][N:64]([CH3:65])[CH3:66].[n:45]1([O:46][C:47]([N:48]([CH3:49])[CH3:50])=[N+:51]([CH3:52])[CH3:53])[c:54]2[cH:55][cH:56][cH:57][cH:58][c:59]2[n:60][n:61]1>>[Br:1][c:2]1[n:3][c:4]([C:18](=[O:20])[NH:25][CH:24]([C:23]([NH:22][CH3:21])=[O:30])[CH2:26][CH:27]([CH3:28])[CH3:29])[c:5]2[n:6]1[CH2:7][CH2:8][N:9]([C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:10]2

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 26255TetrafluoroborateHCID 81531DiisopropylethylamineHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 142849542-amino-N,4-dimethylpentanamideHCID 576354283-bromo-7-[(tert-butoxy)carbonyl]-5H,6H,7H,8H-imidazo[1,5-a]pyrazine-1-carboxylic acid

Product 1

HCID 66932106tert-butyl 3-bromo-1-[[4-methyl-1-(methylamino)-1-oxopentan-2-yl]carbamoyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-7-carboxylate

Sources & evidence

ORD record
ord-ab855946507646409ae851c151e83751
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…