Hydrochloric Acid → 4-[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
Reaction equation
[CH2:44]1[O:45][CH2:46][CH2:47][CH2:48]1.[CH3:42][OH:43].[Cl:3][c:4]1[c:5]([F:40])[c:6]([NH:7][c:8]2[n:9][cH:10][n:11][c:12]3[cH:13][c:14]([O:35][CH3:36])[c:15]([O:18][CH:19]4[CH2:20][CH:21]([C:31](=[O:32])[O:33][CH3:34])[N:22]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:23]4)[cH:16][c:17]23)[cH:37][cH:38][cH:39]1.[ClH:41].[Na+:2].[OH-:1].[OH2:49]>>[Cl:3][c:4]1[c:5]([F:40])[c:6]([NH:7][c:8]2[n:9][cH:10][n:11][c:12]3[cH:13][c:14]([O:35][CH3:36])[c:15]([O:18][CH:19]4[CH2:20][CH:21]([C:31](=[O:32])[OH:33])[N:22]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:23]4)[cH:16][c:17]23)[cH:37][cH:38][cH:39]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-1234460276f4413c9f598f807a0dfc91
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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