Dimethylformamide → N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-morpholinoacetamide

HRID 1118977Notes

Reaction equation

HRID 1118977 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[n:6][n:7](-[c:37]2[cH:38][cH:39][c:40]([CH3:43])[cH:41][cH:42]2)[c:8]([NH:10][C:11]([NH:12][c:13]2[cH:14][cH:15][c:16]([O:23][CH2:24][c:25]3[cH:26][c:27]([NH:31][C:32]([CH2:33][Cl:34])=[O:35])[n:28][cH:29][cH:30]3)[c:17]3[cH:18][cH:19][cH:20][cH:21][c:22]23)=[O:36])[cH:9]1.[CH2:53]1[CH2:54][O:55][CH2:56][CH2:57][NH:58]1.[CH:44]([N:45]([CH2:46][CH3:47])[CH:48]([CH3:49])[CH3:50])([CH3:51])[CH3:52].[Cl:59][CH2:60][Cl:61].[O:62]=[CH:63][N:64]([CH3:65])[CH3:66]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[n:6][n:7](-[c:37]2[cH:38][cH:39][c:40]([CH3:43])[cH:41][cH:42]2)[c:8]([NH:10][C:11]([NH:12][c:13]2[cH:14][cH:15][c:16]([O:23][CH2:24][c:25]3[cH:26][c:27]([NH:31][C:32]([CH2:33][N:58]4[CH2:53][CH2:54][O:55][CH2:56][CH2:57]4)=[O:35])[n:28][cH:29][cH:30]3)[c:17]3[cH:18][cH:19][cH:20][cH:21][c:22]23)=[O:36])[cH:9]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8083MorpholineHCID 81531DiisopropylethylamineHCID 58416746HCID 58416746, compound

Product 1

HCID 45257075N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-morpholinoacetamide

Sources & evidence

ORD record
ord-dbb9b4740ab7428087ec57630a811bf2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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