Tetrahydrofuran → 3-(4-Bromo-2-chloro-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one
Reaction equation
[Br:23][c:24]1[cH:25][c:26]([Cl:32])[c:27]([CH2:30][Br:31])[cH:28][cH:29]1.[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[CH3:16][CH:17]([N-:18][CH:19]([CH3:20])[CH3:21])[CH3:22].[CH3:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43].[F:1][C:2]1([F:14])[CH2:3][CH2:4][CH:5]([N:8]2[C:9](=[O:13])[CH2:10][CH2:11][CH2:12]2)[CH2:6][CH2:7]1.[Li+:15]>>[F:1][C:2]1([F:14])[CH2:3][CH2:4][CH:5]([N:8]2[C:9](=[O:13])[CH:10]([CH2:30][c:27]3[c:26]([Cl:32])[cH:25][c:24]([Br:23])[cH:29][cH:28]3)[CH2:11][CH2:12]2)[CH2:6][CH2:7]1Participants
7
Sources & evidence
- ORD record
- ord-8824e70242af4166a8a4266351181f7f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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