Hydrochloric Acid → 3-(RS)-[2-(4-Bromobenzyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-ylmethyl]-4-(SR)-phenylpyrrolidine-1-carboxylic Acid Tert-Butyl Ester
Reaction equation
[Br:22][c:23]1[cH:24][cH:25][c:26]([CH2:27][N:28]2[C:29](=[O:38])[C:30]3([CH2:31][CH2:32]2)[CH2:33][CH2:34][NH:35][CH2:36][CH2:37]3)[cH:39][cH:40]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH:19]=[O:20])[CH:11]([c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[CH2:12]1.[C:48]([O:49][BH-:50]([O:51][C:52](=[O:53])[CH3:54])[O:55][C:56](=[O:57])[CH3:58])(=[O:59])[CH3:60].[C:61](=[O:62])([OH:63])[O-:64].[CH3:41][CH2:42][N:43]([CH2:44][CH3:45])[CH2:46][CH3:47].[ClH:21].[Na+:65]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH2:19][N:35]2[CH2:34][CH2:33][C:30]3([C:29](=[O:38])[N:28]([CH2:27][c:26]4[cH:25][cH:24][c:23]([Br:22])[cH:40][cH:39]4)[CH2:32][CH2:31]3)[CH2:37][CH2:36]2)[CH:11]([c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[CH2:12]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-ac028036d5594371b4c221e0c7f6d9a3
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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