Acetate → Methyl 4-benzyloxycarbonyl-2-fluorobenzoate

HRID 1120665Notes

Reaction equation

HRID 1120665 reaction equation
[Br:16][c:17]1[cH:18][c:19]([F:27])[c:20]([C:21](=[O:22])[O:23][CH3:24])[cH:25][cH:26]1.[C:33]([O-:34])(=[O:35])[CH3:36].[C:37]([O-:38])(=[O:39])[CH3:40].[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[CH3:28][N:29]([CH:30]=[O:31])[CH3:32].[OH:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[Pd+2:41]>>[O:8]([CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[C:30]([c:17]1[cH:18][c:19]([F:27])[c:20]([C:21](=[O:22])[O:23][CH3:24])[cH:25][cH:26]1)=[O:31]

Participants

7

Reactant 6

HCID 175Acetate2×HCID 244Benzyl AlcoholHCID 6228DimethylformamideHCID 8471TriethylamineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 113453114-Bromo-2-fluoro-benzoic acid methyl ester

Product 1

HCID 59295107Methyl 4-benzyloxycarbonyl-2-fluorobenzoate

Sources & evidence

ORD record
ord-a1f04aa83b5b4567ae3e0e048c71a835
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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