Tetrahydrofuran → Ethyl 3-(4-fluorophenyl)-3-(4-hydroxyphenyl)-acrylate

HRID 1120854Notes

Reaction equation

HRID 1120854 reaction equation
[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:11][Si:12]([CH3:13])([CH3:14])[CH2:15][C:16](=[O:17])[O:18][CH2:19][CH3:20].[CH3:1][Si:2]([CH3:3])([CH3:4])[N-:5][Si:6]([CH3:7])([CH3:8])[CH3:9].[F:21][c:22]1[cH:23][cH:24][c:25]([C:28](=[O:29])[c:30]2[cH:31][cH:32][c:33]([OH:36])[cH:34][cH:35]2)[cH:26][cH:27]1.[Li+:10]>>[CH:15]([C:16](=[O:17])[O:18][CH2:19][CH3:20])=[C:28]([c:25]1[cH:24][cH:23][c:22]([F:21])[cH:27][cH:26]1)[c:30]1[cH:31][cH:32][c:33]([OH:36])[cH:34][cH:35]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 77687Ethyl trimethylsilylacetateHCID 1176664-Fluoro-4'-hydroxybenzophenoneHCID 3280088Npc316347

Product 1

HCID 68674988Ethyl 3-(4-fluorophenyl)-3-(4-hydroxyphenyl)-acrylate

Sources & evidence

ORD record
ord-b75f880309b545ee83b17f009db8b2fc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…