Tetrahydrofuran → ethyl 5-(4-((4-(5-amino-1-(tert-butoxycarbonyl)-4-cyano-1H-pyrazol-3-yl)phenoxy)methyl)phenyl)-2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylate
Reaction equation
[CH2:90]1[O:91][CH2:92][CH2:93][CH2:94]1.[NH2:68][c:69]1[c:70]([C:88]#[N:89])[c:71](-[c:81]2[cH:82][cH:83][c:84]([OH:87])[cH:85][cH:86]2)[n:72][n:73]1[C:74](=[O:75])[O:76][C:77]([CH3:78])([CH3:79])[CH3:80].[c:49]1([P:50]([c:51]2[cH:52][cH:53][cH:54][cH:55][cH:56]2)[c:57]2[cH:58][cH:59][cH:60][cH:61][cH:62]2)[cH:63][cH:64][cH:65][cH:66][cH:67]1.[s:1]1[c:2]([N:10]([C:11](=[O:12])[c:13]2[cH:14][cH:15][cH:16][c:17]3[c:22]2[CH2:21][N:20]([c:23]2[s:24][c:25](-[c:33]4[cH:34][cH:35][c:36]([CH2:39][OH:40])[cH:37][cH:38]4)[c:26]([C:28](=[O:29])[O:30][CH2:31][CH3:32])[n:27]2)[CH2:19][CH2:18]3)[CH2:41][O:42][CH2:43][CH2:44][Si:45]([CH3:46])([CH3:47])[CH3:48])[n:3][c:4]2[c:5]1[cH:6][cH:7][cH:8][cH:9]2>>[s:1]1[c:2]([N:10]([C:11](=[O:12])[c:13]2[cH:14][cH:15][cH:16][c:17]3[c:22]2[CH2:21][N:20]([c:23]2[s:24][c:25](-[c:33]4[cH:34][cH:35][c:36]([CH2:39][O:40][c:84]5[cH:83][cH:82][c:81](-[c:71]6[c:70]([C:88]#[N:89])[c:69]([NH2:68])[n:73]([C:74](=[O:75])[O:76][C:77]([CH3:78])([CH3:79])[CH3:80])[n:72]6)[cH:86][cH:85]5)[cH:37][cH:38]4)[c:26]([C:28](=[O:29])[O:30][CH2:31][CH3:32])[n:27]2)[CH2:19][CH2:18]3)[CH2:41][O:42][CH2:43][CH2:44][Si:45]([CH3:46])([CH3:47])[CH3:48])[n:3][c:4]2[c:5]1[cH:6][cH:7][cH:8][cH:9]2Participants
5
Reactant 4
HCID 8028Tetrahydrofuran
HCID 11776Triphenylphosphine
HCID 59447480ethyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-(hydroxymethyl)phenyl)thiazole-4-carboxylate
HCID 136027725tert-butyl 5-amino-4-cyano-3-(4-hydroxyphenyl)-1H-pyrazole-1-carboxylateProduct 1
Sources & evidence
- ORD record
- ord-817a9016be444f3d82190913c12911a4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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