Methanol → N-[6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1,3-dimethyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]propanamide

HRID 1122087Notes

Reaction equation

HRID 1122087 reaction equation
[C:40](=[O:41])([O-:42])[O-:43].[CH2:46]1[O:47][CH2:48][CH2:49][CH2:50]1.[CH3:38][OH:39].[CH3:51][CH2:52][O:53][C:54]([CH3:55])=[O:56].[Cl:1][c:2]1[c:3](-[c:9]2[c:10](-[c:31]3[cH:32][cH:33][c:34]([Cl:37])[cH:35][cH:36]3)[cH:11][c:12]3[c:13]([N:22]([C:23]([CH2:24][CH3:25])=[O:26])[C:27](=[O:28])[CH2:29][CH3:30])[c:14]([CH3:21])[c:15](=[O:20])[n:16]([CH3:19])[c:17]3[n:18]2)[cH:4][cH:5][c:6]([Cl:8])[cH:7]1.[Cs+:44].[Cs+:45]>>[Cl:1][c:2]1[c:3](-[c:9]2[c:10](-[c:31]3[cH:32][cH:33][c:34]([Cl:37])[cH:35][cH:36]3)[cH:11][c:12]3[c:13]([NH:22][C:23]([CH2:24][CH3:25])=[O:26])[c:14]([CH3:21])[c:15](=[O:20])[n:16]([CH3:19])[c:17]3[n:18]2)[cH:4][cH:5][c:6]([Cl:8])[cH:7]1

Participants

7

Reactant 6

HCID 887MethanolHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 68717076N-(7-(2,4-dichlorophenyl)-6-(4-chlorophenyl)-1,2-dihydro-1,3-dimethyl-2-oxo-1,8-naphthyridin-4-yl)-N-propionylpropionamide

Product 1

HCID 11249076N-[6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1,3-dimethyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]propanamide

Sources & evidence

ORD record
ord-727adb3d54254a0f9c14c1d8adbad117
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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