Morpholine → 8-(1-Ethyl-propyl)-2,6-dimethyl-3-(3-methyl-4-morpholin-4-yl-thiophen-2-yl)-imidazo[1,2-b]pyridazine
Reaction equation
[Br:1][c:2]1[c:3]([CH3:23])[c:4](-[c:7]2[c:8]([CH3:22])[n:9][c:10]3[n:11]2[n:12][c:13]([CH3:21])[cH:14][c:15]3[CH:16]([CH2:17][CH3:18])[CH2:19][CH3:20])[s:5][cH:6]1.[CH2:24]1[CH2:25][O:26][CH2:27][CH2:28][NH:29]1.[CH3:30][N:31]([c:32]1[cH:33][cH:34][cH:35][cH:36][c:37]1-[c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1)[CH3:44].[CH3:71][Si:72]([N-:73][Si:74]([CH3:75])([CH3:76])[CH3:77])([CH3:78])[CH3:79].[CH3:80][CH2:81][O:82][C:83]([CH3:84])=[O:85].[CH:45]1([P:46]([CH:47]2[CH2:48][CH2:49][CH2:50][CH2:51][CH2:52]2)[c:53]2[cH:54][cH:55][cH:56][cH:57][c:58]2-[c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)[CH2:65][CH2:66][CH2:67][CH2:68][CH2:69]1.[Li+:70].[O:106]=[C:107]([CH:108]=[CH:109][c:110]1[cH:111][cH:112][cH:113][cH:114][cH:115]1)[CH:116]=[CH:117][c:118]1[cH:119][cH:120][cH:121][cH:122][cH:123]1.[O:124]=[C:125]([CH:126]=[CH:127][c:128]1[cH:129][cH:130][cH:131][cH:132][cH:133]1)[CH:134]=[CH:135][c:136]1[cH:137][cH:138][cH:139][cH:140][cH:141]1.[O:88]=[C:89]([CH:90]=[CH:91][c:92]1[cH:93][cH:94][cH:95][cH:96][cH:97]1)[CH:98]=[CH:99][c:100]1[cH:101][cH:102][cH:103][cH:104][cH:105]1.[Pd:86].[Pd:87]>>[c:2]1([N:29]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[c:3]([CH3:23])[c:4](-[c:7]2[c:8]([CH3:22])[n:9][c:10]3[n:11]2[n:12][c:13]([CH3:21])[cH:14][c:15]3[CH:16]([CH2:17][CH3:18])[CH2:19][CH3:20])[s:5][cH:6]1Participants
10
Reactant 9
Product 1
Sources & evidence
- ORD record
- ord-1093ebba8d0b4f1b8e90840f2b4f4a30
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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