Hydroxide → N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2-difluorocyclopropanecarboxamide
Reaction equation
[Br:1][c:2]1[c:3]([F:12])[c:4]2[c:5]([n:6][cH:7]1)[nH:8][cH:9][c:10]2[NH2:11].[CH3:21][CH2:22][N:23]([CH2:24][CH3:25])[CH2:26][CH3:27].[Cl:31][CH2:32][Cl:33].[F:13][C:14]1([F:20])[CH:15]([C:17](=[O:18])[OH:19])[CH2:16]1.[Li+:29].[OH-:28].[OH2:30].[OH2:34]>>[Br:1][c:2]1[c:3]([F:12])[c:4]2[c:5]([n:6][cH:7]1)[nH:8][cH:9][c:10]2[NH:11][C:17]([CH:15]1[C:14]([F:13])([F:20])[CH2:16]1)=[O:18]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-1bf8d57974934136aab0bef2edad88ad
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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