Chloride → Tert-butyl 2-fluoro-cyclopropane-1-carboxylate

HRID 1123812Notes

Reaction equation

HRID 1123812 reaction equation
[BH4-:13].[C:16]([O:17][CH3:18])([CH3:19])([CH3:20])[CH3:21].[CH2:23]([N+:24]([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])([CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH3:41])[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH3:48].[CH3:49][c:50]1[cH:51][cH:52][cH:53][cH:54][cH:55]1.[Cl-:22].[Cl:1][C:2]1([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[CH:3]([F:5])[CH2:4]1.[Na+:14].[OH2:15]>>[CH:2]1([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[CH:3]([F:5])[CH2:4]1

Participants

9

Reactant 8

HCID 312ChlorideHCID 923Sodium ionHCID 962WaterHCID 1140TolueneHCID 15413tert-Butyl methyl etherHCID 21219MethyltricaprylylammoniumHCID 28123BorohydrideHCID 11858685Tert-butyl 1-chloro-2-fluoro-cyclopropane-1-carboxylate

Product 1

HCID 11819326Tert-butyl 2-fluoro-cyclopropane-1-carboxylate

Sources & evidence

ORD record
ord-8396adc23d704a5fa4bbc6d995d4171a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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