Sodium ion → Ethyl 7-(1-t-butoxycarbonyl-3-pyrrolidinyloxy)-1-cyclopropyl-6-fluoro1,4-dihydro-4-oxoquinoline-3-carboxylate

HRID 112434Notes

Reaction equation

HRID 112434 reaction equation
[C:22]([CH3:23])([CH3:24])([CH3:25])[O:26][C:27](=[O:28])[N:29]1[CH2:30][CH:31]([OH:34])[CH2:32][CH2:33]1.[CH2:35]1[CH2:36][CH2:37][C:38]2=[N:43][CH2:42][CH2:41][CH2:40][N:39]2[CH2:44][CH2:45]1.[CH:1]1([n:4]2[cH:5][c:6]([C:17](=[O:18])[O:19][CH2:20][CH3:21])[c:7](=[O:16])[c:8]3[cH:9][c:10]([F:15])[c:11]([F:14])[cH:12][c:13]23)[CH2:2][CH2:3]1.[H-:46].[Na+:47].[O:48]=[CH:49][N:50]([CH3:51])[CH3:52]>>[CH:1]1([n:4]2[cH:5][c:6]([C:17](=[O:18])[O:19][CH2:20][CH3:21])[c:7](=[O:16])[c:8]3[cH:9][c:10]([F:15])[c:11]([O:34][CH:31]4[CH2:30][N:29]([C:27]([O:26][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:28])[CH2:33][CH2:32]4)[cH:12][c:13]23)[CH2:2][CH2:3]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 6228DimethylformamideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 166653HydrideHCID 44169391-Boc-3-pyrrolidinolHCID 9817544Ethyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Product 1

HCID 15021537Ethyl 7-(1-t-butoxycarbonyl-3-pyrrolidinyloxy)-1-cyclopropyl-6-fluoro1,4-dihydro-4-oxoquinoline-3-carboxylate

Sources & evidence

ORD record
ord-7393edbdb3ca4b769c74fb1e3f0088b2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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