Toluene → [4-[(2-Chloro-4,4-difluoro-spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-1-(3-fluoro-2-pyridyl)pyrazol-3-yl]methanol
Reaction equation
[C:64]([O:65][CH3:66])([CH3:67])([CH3:68])[CH3:69].[CH2:37]([Al+:38][CH2:39][CH:40]([CH3:41])[CH3:42])[CH:43]([CH3:44])[CH3:45].[CH3:46][c:47]1[cH:48][cH:49][cH:50][cH:51][cH:52]1.[CH3:53][CH2:54][CH2:55][CH2:56][CH2:57][CH3:58].[Cl:1][c:2]1[cH:3][c:4]2[c:5]([s:35]1)[C:6]1([O:7][CH2:8][C:9]2([F:10])[F:11])[CH2:12][CH2:13][N:14]([CH2:17][c:18]2[c:19]([C:30](=[O:31])[O:32][CH2:33][CH3:34])[n:20][n:21](-[c:23]3[n:24][cH:25][cH:26][cH:27][c:28]3[F:29])[cH:22]2)[CH2:15][CH2:16]1.[H-:36].[O:59]1[CH2:60][CH2:61][CH2:62][CH2:63]1>>[Cl:1][c:2]1[cH:3][c:4]2[c:5]([s:35]1)[C:6]1([O:7][CH2:8][C:9]2([F:10])[F:11])[CH2:12][CH2:13][N:14]([CH2:17][c:18]2[c:19]([CH2:30][OH:31])[n:20][n:21](-[c:23]3[n:24][cH:25][cH:26][cH:27][c:28]3[F:29])[cH:22]2)[CH2:15][CH2:16]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-31e3e9c8a59847a693b3b81c0039098d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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