Tetrahydrofuran → 2-(4-Fluoro-phenyl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid (2-fluoro-5-methoxy-4-methyl-phenyl)-amide

HRID 1125589Notes

Reaction equation

HRID 1125589 reaction equation
[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[CH3:15][CH2:16][CH2:17][CH2:18][Li:19].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[NH:9][CH:10]=[CH:11][C:12](=[O:14])[CH2:13]2)[cH:6][cH:7]1.[F:20][c:21]1[c:22]([N:30]=[C:31]=[O:32])[cH:23][c:24]([O:28][CH3:29])[c:25]([CH3:27])[cH:26]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[N:9]([C:31]([NH:30][c:22]3[c:21]([F:20])[cH:26][c:25]([CH3:27])[c:24]([O:28][CH3:29])[cH:23]3)=[O:32])[CH:10]=[CH:11][C:12](=[O:14])[CH2:13]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 593778971-Fluoro-2-isocyanato-4-methoxy-5-methyl-benzeneHCID 669062792-(4-fluorophenyl)-2,3-dihydro-1H-pyridin-4-oneHCID 178418339Butyllithium

Product 1

HCID 669077172-(4-Fluoro-phenyl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid (2-fluoro-5-methoxy-4-methyl-phenyl)-amide

Sources & evidence

ORD record
ord-1978406f4e5c46f1ba8bf1113e73c1ea
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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