1,2-Dichloroethane → 1-[2-[4,6-Bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-2-yl]ethyl]piperidin-4-ol

HRID 1125808Notes

Reaction equation

HRID 1125808 reaction equation
[C:33]([O:34][BH-:35]([O:36][C:37](=[O:38])[CH3:39])[O:40][C:41](=[O:42])[CH3:43])(=[O:44])[CH3:45].[Cl:54][CH2:55][CH2:56][Cl:57].[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]3[c:10]([n:11][c:12](-[c:20]4[cH:21][cH:22][c:23]([F:26])[cH:24][cH:25]4)[c:13]2-[c:14]2[cH:15][cH:16][n:17][cH:18][cH:19]2)[n:27][n:28]([CH2:30][CH:31]=[O:32])[cH:29]3)[cH:6][cH:7]1.[Na+:46].[OH:47][CH:48]1[CH2:49][CH2:50][NH:51][CH2:52][CH2:53]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]3[c:10]([n:11][c:12](-[c:20]4[cH:21][cH:22][c:23]([F:26])[cH:24][cH:25]4)[c:13]2-[c:14]2[cH:15][cH:16][n:17][cH:18][cH:19]2)[n:27][n:28]([CH2:30][CH2:31][N:51]2[CH2:50][CH2:49][CH:48]([OH:47])[CH2:53][CH2:52]2)[cH:29]3)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 111,2-DichloroethaneHCID 923Sodium ionHCID 79341Piperidin-4-olHCID 2724942TriacetoxyborohydrideHCID 86606798HCID 86606798, compound

Product 1

HCID 684448031-[2-[4,6-Bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-2-yl]ethyl]piperidin-4-ol

Sources & evidence

ORD record
ord-dfa8bdb307f5401ca37f89edc380d0a3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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