Hydrochloric Acid → 1-Methyl-4-(6-nitropyridin-3-yl)piperazine

HRID 1126006Notes

Reaction equation

HRID 1126006 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([N+:8](=[O:9])[O-:10])[n:6][cH:7]1.[C:11](=[O:12])([O-:13])[O-:14].[CH2:30]([N+:31]([CH2:32][CH2:33][CH2:34][CH3:35])([CH2:36][CH2:37][CH2:38][CH3:39])[CH2:40][CH2:41][CH2:42][CH3:43])[CH2:44][CH2:45][CH3:46].[CH3:17][N:18]1[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]1.[CH3:25][S:26]([CH3:27])=[O:28].[ClH:24].[I-:29].[K+:15].[K+:16]>>[c:2]1([N:21]2[CH2:20][CH2:19][N:18]([CH3:17])[CH2:23][CH2:22]2)[cH:3][cH:4][c:5]([N+:8](=[O:9])[O-:10])[n:6][cH:7]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 16028TetrabutylammoniumHCID 19660Carbonate IonHCID 30165Iodide IonHCID 531671-MethylpiperazineHCID 8176205-Bromo-2-nitropyridine

Product 1

HCID 517114841-Methyl-4-(6-nitropyridin-3-yl)piperazine

Sources & evidence

ORD record
ord-b6d8bc8a3af848bb83f9677c32face97
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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