Hydrochloric Acid → 7-[(4-aminopiperidin-1-yl)methyl]-3,4-dihydroquinolin-2(1H)-one

HRID 1126750Notes

Reaction equation

HRID 1126750 reaction equation
[CH3:1][CH2:2][O:3][C:4]([CH3:5])=[O:6].[CH3:34][CH2:35][O:36][C:37]([CH3:38])=[O:39].[Cl:40][CH:41]([Cl:42])[Cl:43].[ClH:33].[O:7]=[C:8]1[NH:9][c:10]2[cH:11][c:12]([CH2:18][N:19]3[CH2:20][CH2:21][CH:22]([NH:25][C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:23][CH2:24]3)[cH:13][cH:14][c:15]2[CH2:16][CH2:17]1.[OH2:44]>>[O:7]=[C:8]1[NH:9][c:10]2[cH:11][c:12]([CH2:18][N:19]3[CH2:20][CH2:21][CH:22]([NH2:25])[CH2:23][CH2:24]3)[cH:13][cH:14][c:15]2[CH2:16][CH2:17]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 6212ChloroformHCID 8857Ethyl Acetate2×HCID 86655981Tert-butyl {1-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)methyl]piperidin-4-yl}carbamate

Product 1

HCID 673214667-[(4-aminopiperidin-1-yl)methyl]-3,4-dihydroquinolin-2(1H)-one

Sources & evidence

ORD record
ord-c6abb62c486044bfb8447810ffd971f4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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