Dimethylformamide → 1-[1-(4-Chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid [3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-amide

HRID 1126903Notes

Reaction equation

HRID 1126903 reaction equation
[Br:58][c:59]1[cH:60][c:61]([NH2:71])[cH:62][c:63](-[c:65]2[n:66][n:67][n:68][n:69]2[CH3:70])[cH:64]1.[CH:25]([N:26]([CH2:27][CH3:28])[CH:29]([CH3:30])[CH3:31])([CH3:32])[CH3:33].[Cl:1][c:2]1[c:3]([CH3:24])[cH:4][c:5]([CH2:6][N:7]2[CH2:8][CH2:9][CH:10]([N:13]3[CH:14]([C:19](=[O:20])[OH:21])[CH2:15][CH2:16][C:17]3=[O:18])[CH2:11][CH2:12]2)[cH:22][cH:23]1.[O:72]=[CH:73][N:74]([CH3:75])[CH3:76].[P-:34]([F:35])([F:36])([F:37])([F:38])([F:39])[F:40].[n:41]1([O:42][C:43]([N:44]([CH3:45])[CH3:46])=[N+:47]([CH3:48])[CH3:49])[c:50]2[n:51][cH:52][cH:53][cH:54][c:55]2[n:56][n:57]1>>[Cl:1][c:2]1[c:3]([CH3:24])[cH:4][c:5]([CH2:6][N:7]2[CH2:8][CH2:9][CH:10]([N:13]3[CH:14]([C:19](=[O:21])[NH:71][c:61]4[cH:60][c:59]([Br:58])[cH:64][c:63](-[c:65]5[n:66][n:67][n:68][n:69]5[CH3:70])[cH:62]4)[CH2:15][CH2:16][C:17]3=[O:18])[CH2:11][CH2:12]2)[cH:22][cH:23]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 667333043-Bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenylamineHCID 667333601-[1-(4-Chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid

Product 1

HCID 667350421-[1-(4-Chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid [3-bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenyl]-amide

Sources & evidence

ORD record
ord-c6fbb3a7d732478c835a9582a080a2ad
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…