Dimethylformamide → tert-Butyl 2-(5-(2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamido)-6-methyl-1-oxoisoquinolin-2(1H)-yl)ethyl(methyl)carbamate
Reaction equation
[CH3:49][N:50]([CH3:51])[CH:52]=[O:53].[CH:40]([N:41]([CH2:42][CH3:43])[CH:44]([CH3:45])[CH3:46])([CH3:47])[CH3:48].[F:25][c:26]1[cH:27][c:28]([CH2:36][C:37](=[O:38])[OH:39])[cH:29][cH:30][c:31]1[C:32]([F:33])([F:34])[F:35].[NH2:1][c:2]1[c:3]2[cH:4][cH:5][n:6]([CH2:14][CH2:15][N:16]([C:17]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:23])[CH3:24])[c:7](=[O:13])[c:8]2[cH:9][cH:10][c:11]1[CH3:12]>>[NH:1]([c:2]1[c:3]2[cH:4][cH:5][n:6]([CH2:14][CH2:15][N:16]([C:17]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:23])[CH3:24])[c:7](=[O:13])[c:8]2[cH:9][cH:10][c:11]1[CH3:12])[C:37]([CH2:36][c:28]1[cH:27][c:26]([F:25])[c:31]([C:32]([F:33])([F:34])[F:35])[cH:30][cH:29]1)=[O:38]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-8b9cc209b0514fbbb6d5617ada2d3968
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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