Hydrochloric Acid → tert-Butyl 3-{4-bromo-3-[isobutyryl-(2-triisopropylsilanyloxyethyl)amino]benzyloxy}-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate
Reaction equation
[Br:1][c:2]1[c:3]([NH:43][C:44]([CH:45]([CH3:46])[CH3:47])=[O:48])[cH:4][c:5]([CH2:6][O:7][CH:8]2[CH2:9][N:10]([C:34](=[O:35])[O:36][C:37]([CH3:38])([CH3:39])[CH3:40])[CH2:11][CH2:12][CH:13]2[c:14]2[cH:15][cH:16][c:17]([O:20][CH2:21][CH2:22][CH2:23][O:24][CH2:25][c:26]3[c:27]([O:32][CH3:33])[cH:28][cH:29][cH:30][cH:31]3)[cH:18][cH:19]2)[cH:41][cH:42]1.[CH3:66][N:67]([CH3:68])[CH:69]=[O:70].[ClH:65].[H-:49].[I:51][CH2:52][CH2:53][O:54][Si:55]([CH:56]([CH3:57])[CH3:58])([CH:59]([CH3:60])[CH3:61])[CH:62]([CH3:63])[CH3:64].[Na+:50]>>[Br:1][c:2]1[c:3]([N:43]([C:44]([CH:45]([CH3:46])[CH3:47])=[O:48])[CH2:52][CH2:53][O:54][Si:55]([CH:56]([CH3:57])[CH3:58])([CH:59]([CH3:60])[CH3:61])[CH:62]([CH3:63])[CH3:64])[cH:4][c:5]([CH2:6][O:7][CH:8]2[CH2:9][N:10]([C:34](=[O:35])[O:36][C:37]([CH3:38])([CH3:39])[CH3:40])[CH2:11][CH2:12][CH:13]2[c:14]2[cH:15][cH:16][c:17]([O:20][CH2:21][CH2:22][CH2:23][O:24][CH2:25][c:26]3[c:27]([O:32][CH3:33])[cH:28][cH:29][cH:30][cH:31]3)[cH:18][cH:19]2)[cH:41][cH:42]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-b847070ae60b4d17b3d0ff42be2ff105
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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