Acetic Acid → tert-Butyl 4-hydroxy-[1,4'-bipiperidine]-1'-carboxylate

HRID 1128006Notes

Reaction equation

HRID 1128006 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11](=[O:14])[CH2:12][CH2:13]1.[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[CH3:22][C:23](=[O:24])[OH:25].[OH:15][CH:16]1[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([N:19]2[CH2:18][CH2:17][CH:16]([OH:15])[CH2:21][CH2:20]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 8028TetrahydrofuranHCID 79341Piperidin-4-olHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 9835508tert-Butyl 4-hydroxy-[1,4'-bipiperidine]-1'-carboxylate

Sources & evidence

ORD record
ord-58b068c4a2b9462699d33ae26be43447
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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