Dimethylformamide → N-[4-[5-[[2-[tert-butyl(dimethyl)silyl]oxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]-methylamino]pent-1-ynyl]phenyl]-2,2,2-trifluoroacetamide
Reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][C:5]#[C:6][c:7]1[cH:8][cH:9][c:10]([NH:13][C:14]([C:15]([F:16])([F:17])[F:18])=[O:19])[cH:11][cH:12]1.[C:20]([CH3:21])([CH3:22])([CH3:23])[Si:24]([O:25][CH:26]([CH2:27][NH:28][CH3:29])[c:30]1[c:31]2[cH:32][cH:33][c:34](=[O:41])[nH:35][c:36]2[c:37]([OH:40])[cH:38][cH:39]1)([CH3:42])[CH3:43].[CH2:59]([N+:60]([CH2:61][CH2:62][CH2:63][CH3:64])([CH2:65][CH2:66][CH2:67][CH3:68])[CH2:69][CH2:70][CH2:71][CH3:72])[CH2:73][CH2:74][CH3:75].[CH:44]([N:45]([CH2:46][CH3:47])[CH:48]([CH3:49])[CH3:50])([CH3:51])[CH3:52].[I-:58].[O:53]=[CH:54][N:55]([CH3:56])[CH3:57]>>[CH2:2]([CH2:3][CH2:4][C:5]#[C:6][c:7]1[cH:8][cH:9][c:10]([NH:13][C:14]([C:15]([F:16])([F:17])[F:18])=[O:19])[cH:11][cH:12]1)[N:28]([CH2:27][CH:26]([O:25][Si:24]([C:20]([CH3:21])([CH3:22])[CH3:23])([CH3:42])[CH3:43])[c:30]1[c:31]2[cH:32][cH:33][c:34](=[O:41])[nH:35][c:36]2[c:37]([OH:40])[cH:38][cH:39]1)[CH3:29]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-c0dde9c2c8f249a7925beded05827a13
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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