Potassium Cation → Ethyl 4-chloro-3-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)benzoate

HRID 1128809Notes

Reaction equation

HRID 1128809 reaction equation
[CH3:134][c:135]1[cH:136][cH:137][cH:138][cH:139][cH:140]1.[CH3:21][c:22]1[n:23][c:24]([NH2:27])[s:25][cH:26]1.[Cl:1][c:2]1[c:3]([O:13][c:14]2[cH:15][c:16]([Cl:20])[n:17][cH:18][cH:19]2)[cH:4][c:5]([C:6](=[O:7])[O:8][CH2:9][CH3:10])[cH:11][cH:12]1.[K+:33].[K+:34].[K+:35].[O:116]=[C:117]([CH:118]=[CH:119][c:120]1[cH:121][cH:122][cH:123][cH:124][cH:125]1)[CH:126]=[CH:127][c:128]1[cH:129][cH:130][cH:131][cH:132][cH:133]1.[O:80]=[C:81]([CH:82]=[CH:83][c:84]1[cH:85][cH:86][cH:87][cH:88][cH:89]1)[CH:90]=[CH:91][c:92]1[cH:93][cH:94][cH:95][cH:96][cH:97]1.[O:98]=[C:99]([CH:100]=[CH:101][c:102]1[cH:103][cH:104][cH:105][cH:106][cH:107]1)[CH:108]=[CH:109][c:110]1[cH:111][cH:112][cH:113][cH:114][cH:115]1.[OH2:141].[P:28]([O-:29])([O-:30])([O-:31])=[O:32].[Pd:78].[Pd:79].[c:36]1([P:37]([c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)[c:44]2[c:45]3[c:69]([cH:70][cH:71][cH:72]2)[C:66]([CH3:67])([CH3:68])[c:48]2[c:47]([c:52]([P:53]([c:54]4[cH:55][cH:56][cH:57][cH:58][cH:59]4)[c:60]4[cH:61][cH:62][cH:63][cH:64][cH:65]4)[cH:51][cH:50][cH:49]2)[O:46]3)[cH:73][cH:74][cH:75][cH:76][cH:77]1>>[Cl:1][c:2]1[c:3]([O:13][c:14]2[cH:15][c:16]([NH:27][c:24]3[n:23][c:22]([CH3:21])[cH:26][s:25]3)[n:17][cH:18][cH:19]2)[cH:4][c:5]([C:6](=[O:7])[O:8][CH2:9][CH3:10])[cH:11][cH:12]1

Participants

10

Reactant 9

HCID 813Potassium Cation3×HCID 962WaterHCID 1061PhosphateHCID 1140TolueneHCID 23938Palladium2×HCID 741432-Amino-4-methylthiazoleHCID 95417Dibenzylidene acetone3×HCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)HCID 86634737Ethyl 4-chloro-3-(2-chloropyridin-4-yloxy)benzoate

Product 1

HCID 24826662Ethyl 4-chloro-3-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)benzoate

Sources & evidence

ORD record
ord-52e9bc3cccb94485a0e8e07fa20e5c50
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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