Dichloromethane → 1-{3-[3-Chloro-5-(2-methyl-2H-[1,2,4]triazol-3-yl)-thiophen-2-yl]-2,6-dimethyl-imidazo[1,2-b]pyridazin-8-yl}-butan-1-one

HRID 1129360Notes

Reaction equation

HRID 1129360 reaction equation
[CH2:39]1[CH2:40][CH2:41][CH2:42][O:43]1.[CH2:44]([c:45]1[cH:46][cH:47][cH:48][cH:49][cH:50]1)[CH3:51].[CH2:52]1[O:53][CH2:54][CH2:55][CH2:56]1.[CH3:25][CH:26]([N-:27][CH:28]([CH3:29])[CH3:30])[CH3:31].[CH3:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38].[Cl:1][c:2]1[c:3](-[c:13]2[c:14]([CH3:23])[n:15][c:16]3[n:17]2[n:18][c:19]([CH3:22])[cH:20][cH:21]3)[s:4][c:5](-[c:7]2[n:8]([CH3:12])[n:9][cH:10][n:11]2)[cH:6]1.[Cl:57][CH2:58][Cl:59].[Li+:24]>>[Cl:1][c:2]1[c:3](-[c:13]2[c:14]([CH3:23])[n:15][c:16]3[n:17]2[n:18][c:19]([CH3:22])[cH:20][c:21]3[C:42]([CH2:41][CH2:40][CH3:39])=[O:43])[s:4][c:5](-[c:7]2[n:8]([CH3:12])[n:9][cH:10][n:11]2)[cH:6]1

Participants

8

Reactant 7

HCID 6344DichloromethaneHCID 7500EthylbenzeneHCID 8028Tetrahydrofuran2×HCID 8900HeptaneHCID 28486Lithium ionHCID 5062348DiisopropylamideHCID 57932899HCID 57932899, compound

Product 1

HCID 579330721-{3-[3-Chloro-5-(2-methyl-2H-[1,2,4]triazol-3-yl)-thiophen-2-yl]-2,6-dimethyl-imidazo[1,2-b]pyridazin-8-yl}-butan-1-one

Sources & evidence

ORD record
ord-7c421cd23a304ff9906bfc2557b80bce
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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