Tetrahydrofuran → 3-[3-(1-Ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-4-(2,2,2-trifluoro-ethoxy)-phenyl]-acrylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH2:8][P:9](=[O:10])([O:11][CH3:12])[O:13][CH3:14].[CH2:15]([Li:16])[CH2:17][CH2:18][CH3:19].[CH2:20]([CH3:21])[N:22]1[C:23](=[O:49])[CH2:24][C:25]([CH3:47])([CH3:48])[c:26]2[cH:27][c:28]([CH3:46])[c:29](-[c:32]3[cH:33][c:34]([CH:35]=[O:36])[cH:37][cH:38][c:39]3[O:40][CH2:41][C:42]([F:43])([F:44])[F:45])[cH:30][c:31]21.[CH2:50]1[O:51][CH2:52][CH2:53][CH2:54]1.[CH2:64]1[O:65][CH2:66][CH2:67][CH2:68]1.[CH3:55][N:56]1[CH2:57][CH2:58][CH2:59][N:60]([CH3:61])[C:62]1=[O:63]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH:8]=[CH:35][c:34]1[cH:33][c:32](-[c:29]2[c:28]([CH3:46])[cH:27][c:26]3[c:31]([cH:30]2)[N:22]([CH2:20][CH3:21])[C:23](=[O:49])[CH2:24][C:25]3([CH3:47])[CH3:48])[c:39]([O:40][CH2:41][C:42]([F:43])([F:44])[F:45])[cH:38][cH:37]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-83704c020b6c4a5dad2f86e1520e283f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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