Piperidine → trans-N-methyl-N-[4-(4-piperidin-1-yl-butoxymethyl)-cyclohexylmethyl]-4-trifluoromethyl-benzenesulfonamide

HRID 1130191Notes

Reaction equation

HRID 1130191 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][CH2:7][CH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][N:15]([S:16](=[O:17])(=[O:18])[c:19]2[cH:20][cH:21][c:22]([C:25]([F:26])([F:27])[F:28])[cH:23][cH:24]2)[CH3:29])[CH2:12][CH2:13]1.[CH2:30]1[CH2:31][CH2:32][NH:33][CH2:34][CH2:35]1.[CH3:36][N:37]([CH3:38])[C:39](=[O:40])[CH3:41]>>[CH2:2]([CH2:3][CH2:4][CH2:5][O:6][CH2:7][CH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][N:15]([S:16](=[O:17])(=[O:18])[c:19]2[cH:20][cH:21][c:22]([C:25]([F:26])([F:27])[F:28])[cH:23][cH:24]2)[CH3:29])[CH2:12][CH2:13]1)[N:33]1[CH2:32][CH2:31][CH2:30][CH2:35][CH2:34]1

Participants

4

Reactant 3

HCID 8082PiperidineHCID 31374DimethylacetamideHCID 22294178trans-N-[4-(4-bromo-butoxymethyl)-cyclohexylmethyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide

Product 1

HCID 22294235trans-N-methyl-N-[4-(4-piperidin-1-yl-butoxymethyl)-cyclohexylmethyl]-4-trifluoromethyl-benzenesulfonamide

Sources & evidence

ORD record
ord-40e3196fef9341ae8812c5535dade71d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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