Methane → 4-(3-methyl-1,6-diazaspiro[3.5]non-6-yl)-7H-pyrrolo[2,3-d]pyrimidine

HRID 1130279Notes

Reaction equation

HRID 1130279 reaction equation
[C:37].[CH2:1]([O:2][C:3](=[O:4])[N:11]1[CH2:12][CH:13]([CH3:29])[C:14]12[CH2:15][N:16]([c:20]1[c:21]3[c:22]([n:23][cH:24][n:25]1)[nH:26][cH:27][cH:28]3)[CH2:17][CH2:18][CH2:19]2)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[CH3:35][OH:36].[O:30]1[CH2:31][CH2:32][CH2:33][CH2:34]1.[Pd:38]>>[NH:11]1[CH2:12][CH:13]([CH3:29])[C:14]12[CH2:15][N:16]([c:20]1[c:21]3[c:22]([n:23][cH:24][n:25]1)[nH:26][cH:27][cH:28]3)[CH2:17][CH2:18][CH2:19]2

Participants

6

Reactant 5

HCID 297MethaneHCID 887MethanolHCID 8028TetrahydrofuranHCID 23938PalladiumHCID 582932883-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.5]nonane-1-carboxylic acid benzyl ester

Product 1

HCID 582933114-(3-methyl-1,6-diazaspiro[3.5]non-6-yl)-7H-pyrrolo[2,3-d]pyrimidine

Sources & evidence

ORD record
ord-b0668c35437a4be8b945392a719f1c2e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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